抗精神病药物作用的神经生理学机理的研究,倾向于支持 Carlsson 的多巴胺能阻断学说。它的各种临床作用与其在脑内不同部位的多巴胺阻滞活动有关。抗精神病效能可归于对边缘系统和大脑皮层内侧区域的多巴胺受体的阻滞作用,而锥体外系作用可能是由于黑质纹状体的多巴胺能神经元被阻滞的结果。各种神经阻滞剂对非多巴胺能系统 Studies of the neurophysiological mechanisms of antipsychotic effects tend to support Carlsson’s theory of dopaminergic blockade. Its various clinical effects are related to its blockade of dopamine in different parts of the brain. Antipsychotic efficacy can be attributed to the blockade of dopamine receptors on the marginal system and the medial area of ​​the cerebral cortex, whereas extrapyramidal action may be the result of blockage of dopaminergic neurons in the nigrostriatum. Various Nerve Blockers on Non-Dopaminergic Systems