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本文分析了45例小儿苯丙酮尿症(PKU)患儿的脑电图(EEG)变化,发现首次EEG异常率为44.4％,主要表现为阵发或非阵发性棘、尖波及慢活动,少数人显示高峰节律紊乱波型。当将EEG的变化与PKU患儿的年龄、性别、临床的抽搐症状进行比较时,发现7个月～2岁年龄组的EEG异常率最高,而性别差异不明显,临床有抽搐症状时,EEG异常率明显增高。文中还分析了7例新生儿PKU筛查阳性病例,当低苯丙氨酸饮食治疗后,发现血苯丙氨酸浓度下降,EEG改善、临床情况良好,因此,在治疗中EEG可以作为一项有用的监测指标。
In this paper, the changes of electroencephalogram (EEG) in 45 pediatric patients with phenylketonuria (PKU) were analyzed. The abnormal rate of EEG was 44.4% for the first time. The main manifestations were intermittent or non-paroxysmal spikes, sharp wave and slow activity, A few people show patterns of peak rhythm disorders. When comparing the changes of EEG with those of children with PKU, the EEG abnormalities were found to be the highest in 7 months to 2 years of age, while the gender differences were not obvious. When the clinical symptoms were convulsions, EEG Abnormal rate was significantly higher. The paper also analyzed 7 cases of neonatal PKU screening positive cases, when the low phenylalanine diet, the blood phenylalanine concentration decreased, EEG improved, the clinical situation is good, therefore, in the treatment of EEG can be used as a Useful monitoring indicators.