论文部分内容阅读
新药的设计目前正在经历一次革命,因为许多学科领域亦正在取得巨大的突破,如:蛋白质的纯化方法、基因序列分析方法、重组DNA技术、蛋白质结晶学、计算机制图学和理论生物化学等。应用这些知识可以从原子水平解释蛋白质的空间结构。对这些结构的探讨为医学化学家得到具有选择性的有效的抑制剂提供了详细的论据,并且告诉我们哪些化合物不需再试验,显然这类化合物分子的最终衍生物未能适应其合适的活性部位中。因此借助于最新生化技术和医学化学技术的相互促进作用及技术相近的特点,开发新药的前景是很诱人的。
The design of new drugs is currently undergoing a revolution because many fields of research are making tremendous breakthroughs, such as protein purification methods, gene sequence analysis methods, recombinant DNA technology, protein crystallography, computational cartography and theoretical biochemistry. Applying this knowledge can explain the spatial structure of a protein at the atomic level. The discussion of these structures provides the medical chemist with detailed arguments for obtaining selective and potent inhibitors and tells us which compounds need not be retested, and it is clear that the final derivatives of these compounds failed to adapt to their proper activity Parts. Therefore, with the help of the mutual promotion of the latest biochemical technologies and medical chemistry technologies and the similar characteristics of technologies, the prospect of developing new drugs is very attractive.