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目的探讨甘精胰岛素联合阿卡波糖治疗老年2型糖尿病的临床疗效。方法选取湖南泰和医院2015年6月—2016年6月收治的老年2型糖尿病患者80例,按照随机数字表法分为对照组和观察组,各40例。患者入院后均接受糖尿病健康知识宣教,并进行饮食控制和运动疗法。对照组患者给予门冬胰岛素30R皮下注射治疗,观察组患者给予甘精胰岛素皮下注射联合阿卡波糖口服治疗,两组患者均连续治疗12周。比较两组患者治疗后空腹血糖(FBG)、餐后2 h血糖(2 h BG)、糖化血红蛋白(Hb A1c),体质指数(BMI)及治疗期间低血糖、胃肠道反应等并发症发生情况。结果治疗后,观察组患者FBG、2 h BG、Hb Alc和BMI低于对照组(P<0.05)。观察组患者低血糖、胃肠道反应发生率低于对照组(P<0.05)。结论甘精胰岛素联合阿卡波糖治疗老年2型糖尿病临床疗效明显,可有效控制血压,降低并发症发生风险。
Objective To investigate the clinical efficacy of glargine combined with acarbose in the treatment of type 2 diabetes in the elderly. Methods Eighty elderly patients with type 2 diabetes mellitus admitted to Taihe Hospital of Tai’an from June 2015 to June 2016 were randomly divided into control group and observation group according to random number table. Patients admitted to hospital after receiving knowledge of diabetes health education, and diet control and exercise therapy. Patients in the control group were treated with insulin aspart 30R subcutaneously. The patients in the observation group were treated with insulin glargine subcutaneously and acarbose. Both groups were treated for 12 weeks continuously. The incidences of complications such as fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h BG), Hb A1c, body mass index (BMI) and hypoglycemia and gastrointestinal reactions during treatment were compared between the two groups . Results After treatment, FBG, 2 h BG, Hb Alc and BMI in observation group were lower than those in control group (P <0.05). The incidence of hypoglycemia and gastrointestinal reaction in observation group was lower than that in control group (P <0.05). Conclusion The combination of glargine and acarbose has obvious curative effect on type 2 diabetes in elderly patients, which can effectively control blood pressure and reduce the risk of complications.