论文部分内容阅读
目的：探讨实验性急性肝功不全时中分子物质的变化和肠道吸附剂的作用。方法：用１０％Ｄ－氨基半乳糖胺生理盐水腹腔注射造成大鼠急性肝功不全模型。结果：急性肝功不全组较对照组血浆中分子物质明显升高（Ｐ＜０．００５），白蛋白和血糖则显著降低（Ｐ＜０．００５，Ｐ＜０．００１），而血胰岛素、ＢＵＮ和Ｃｒ含量均无明显改变（Ｐ＞０．０５）。肠道吸附剂＋急性肝功不全组较急性肝功不全组血浆中分子物质明显降低（Ｐ＜０．００１），血糖明显升高（Ｐ＜０．０５），而白蛋白则无明显变化（Ｐ＞０．０５）。结论：血浆中分子物质参与急性肝功不全的发病，影响白蛋白合成及血糖水平，肠道吸附剂在吸附降低中分子物质的同时可调整血糖水平。
Objective: To investigate the changes of molecular substances and the role of intestinal adsorbents in experimental acute hepatic insufficiency. Methods: Acute hepatic insufficiency was induced by intraperitoneal injection of 10% D-galactosamine saline in rats. Results: Compared with the control group, plasma molecular weight was significantly increased (P <0.005), albumin and blood glucose were significantly lower (P <0.005, P <0.001), while serum insulin, BUN and Cr content had no significant change (P> 0.05). Intestinal adsorbent + acute hepatic insufficiency (P <0.001), blood glucose significantly increased (P <0.05) and no significant change in albumin compared with acute hepatic insufficiency P> 0.05). CONCLUSION: The plasma molecular substances are involved in the pathogenesis of acute hepatic insufficiency, affecting albumin synthesis and blood glucose levels. Gut absorbents can regulate blood sugar levels while reducing the adsorption of medium molecular substances.