近日,来自美国和韩国的科学家们在国际学术期刊Cancerresearch上发表了一项最新研究进展,他们发现一种具有基因毒性的小分子能够对存在DNA错配修复机制缺陷的癌细胞发挥特异性杀伤作用。该研究为癌症的精准治疗提供了一种新选择。利用具有基因毒性的小分子干扰癌细胞的分裂是开发化疗药物的一个主要目标,但是存在DNA错配修复缺陷的癌细胞会对大多数传 Recently, scientists from the United States and South Korea published a new research report in the international academic journal Cancerresearch. They found that a genotoxic small molecule can specifically kill cancer cells that are deficient in DNA mismatch repair mechanism . The study provides a new option for the precise treatment of cancer. The use of genotoxic small molecules to interfere with the division of cancer cells is a major goal of chemotherapeutic drugs, but the presence of DNA mismatch repair defects in cancer cells will pass most