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目的 探讨儿童肾透明细胞癌病理形态特点及癌细胞DNA含量和倍体的关系。方法 对 4例儿童肾透明细胞癌组织进行病理形态观察 ,并用图象分析仪对癌细胞DNA进行定量分析。结果 4例癌细胞胞质透明呈透明细胞且有乳头状结构 ,其中 2例乳头状结构超过 5 0 % ,3例均见钙化小体及明显出血坏死 ;DNA检测 :DNA平均指数 1.31,呈 2倍体型 ,高 2倍体型或亚 4倍体型。结论 儿童肾透明细胞癌病理形态特点为癌细胞胞质透明 ,以乳头状结构为主 ,可见钙化小体 ,常伴出血、坏死 ,癌周肾小球、肾小管基本正常为特征。癌细胞DNA呈 2倍体或高 2倍体型或亚 4倍体型。
Objective To investigate the pathological features of renal clear cell carcinoma and the relationship between DNA content and ploidy in cancer cells. Methods Four cases of renal clear cell carcinoma were observed histopathologically. DNA was quantified by image analyzer. Results The cytoplasm of 4 cancer cells were transparent and papillary. The papillary structures in 2 cases were over 50%. The calcification bodies and hemorrhagic necrosis were seen in 3 cases. DNA test showed that the average DNA index was 1.31 Ploidy, high 2-fold or sub-4-fold body type. Conclusions The pathological features of renal clear cell carcinoma in children are the cytoplasm of the cancer cells are transparent. The papillary structures are the main features of calcified corpuscles. They are often characterized by hemorrhage, necrosis, glomerulus and renal tubules. Cancer cell DNA was 2-fold or high 2-fold or sub-4-fold.