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目的 :我们在慢性粒细胞白血病 (ＣＭＬ)急变研究中发现ＣＭＬ急变细胞ｂｃｌ- 2基因表达明显高于慢性期 ,甚至高于其他急性粒细胞白血病 (中华血液学杂志 ,1 999,2 0 :2 7) ;而ＣＭＬ急变时化疗反应甚差 ,是目前白血病治疗难题之一。为了进一步阐明Ｂｃｌ- 2基因在ＣＭＬ急变?
PURPOSE: We found that in chronic myeloid leukemia (CML) acute studies, the expression of bcl-2 gene was significantly higher in chronic myeloid leukemia cells than in other chronic myelogenous leukemias (C999) 7); while CML acute chemotherapy response is poor, is currently one of the problems of leukemia treatment. In order to further clarify the Bcl-2 gene mutation in CML?