【摘 要】
：
A novel and viable palladium-catalyzed sequential cyclization/functionalization of alkynone O-methyloximes with unactivated vinyl ethers under aerobic conditions was described.The structure of the products could be successfully controlled by varying the n
【机 构】
：
Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Che
论文部分内容阅读
A novel and viable palladium-catalyzed sequential cyclization/functionalization of alkynone O-methyloximes with unactivated vinyl ethers under aerobic conditions was described.The structure of the products could be successfully controlled by varying the nature of the substituents of the vinyl ethers.This new approach provides a convenient and straightforward synthetic protocol for the prep-aration of structurally diverse 4-(1-alkoxyvinyl)-isoxazoles and 4-vinylisoxazoles in moderate to good yields with highly regioselectivity.Remarkably,this protocol can be performed on a gram scale,showing the promising application in synthetic and pharmaceutical chemistry.
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