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国产麦迪霉素(Mydecamycin,Mydem-ycin)系从四川南川土壤中分离到的链霉菌74-10204(生米加链霉菌四川变种Strep-tomyces mycarofaciens Sichunensis n.Var.)产生的一个大环内酯类抗生素。麦迪霉素口服粉剂曾进行了药理试验,并经临床试用疗效较好,于1977年经国家鉴定。为了提高血药浓度以应临床急性感染和重症患者治疗的要求,四川抗菌素工业研究所与天津和平制药厂又试制了若干种不同工艺路线的注射剂。本文报导麦迪霉素酒石酸盐和菸酰胺盐酸盐两种注射剂的临床前药理试验,并与柱晶白霉素酒石酸盐、红霉素乳糖酸盐做了一些比较。
A domestic macrolide (Mydecamycin, Mycinofaciens Sichunensis n.Var.) Strain of Streptomyces sp. 74-10204 (Streptomyces mycarofaciens Sichunensis n. Var.) Isolated from soil in Nanchuan, Sichuan, Antibiotics. Midecamycin oral powder has been carried out pharmacological tests, and better clinical trials, in 1977 by the national identification. In order to improve blood concentration in order to meet the requirements of clinical acute infection and treatment of critically ill patients, Sichuan Institute of Antibiotics and Tianjin Peace Pharmaceutical Factory have trial-produced several injections of different technological routes. This article reports the preclinical pharmacological tests of two injections of midecamycin tartrate and nicotinamide hydrochloride and compares them with leucomycin tartrate and erythromycin lactobionate.