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目的研究遗传性痉挛性截瘫的临床表现和遗传特点。方法回顾性分析12例患者的临床资料。结果本组起病年龄为10～52岁,平均年龄22岁;35岁以下11例,35岁以上1例;单纯型9例,复杂型3例;3个家族有阳性家族史,共7例患者,散发病例5例。结论本组遗传性痉挛性截瘫患者多于青少年或青年发病,男性多于女性,单纯性较复杂型多见,遗传方式以常染色体显性遗传多见。
Objective To study the clinical manifestations and genetic characteristics of hereditary spastic paraplegia. Methods The clinical data of 12 patients were retrospectively analyzed. Results The onset age of this group was 10 to 52 years old, with an average age of 22 years; 11 cases below 35 years old and 1 case over 35 years old; 9 cases of simple type and 3 cases of complex type; 3 families had a positive family history of 7 cases Patients, sporadic cases in 5 cases. Conclusion This group of patients with hereditary spastic paraplegia more than adolescents or young people, more men than women, simple and more common more complex, genetic ways common autosomal dominant.