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目的探讨舒肝解郁胶囊在癫痫伴抑郁患者治疗中的临床效果。方法将我院2013年8月至2015年2月期间收治的136例癫痫伴抑郁患者分成两组,对照组采用开放性治疗方法治疗,研究组在此基础上加用舒肝解郁胶囊。采用汉密尔顿抑郁量表(HAMD)和癫痫患者生活质量量表(QOLIE-31)评估患者治疗前后的抑郁程度和生活质量,同时比较患者治疗前后的癫痫发作频率和不良反应。结果治疗3个月后,研究组患者的HAMD评分、癫痫发作频率显著低于对照组(P<0.01),QOLIE-31评分明显高于对照组(P<0.01),两组之间的不良反应无统计学差异(P>0.05)。结论舒肝解郁胶囊能够有效改善癫痫患者的抑郁症状,减少癫痫发作次数,且具有较高的安全性。
Objective To investigate the clinical effect of Shugan Jieyu capsule in the treatment of epilepsy with depression. Methods 136 cases of epilepsy with depression treated in our hospital from August 2013 to February 2015 were divided into two groups. The control group was treated with open treatment. The study group was treated with Shugan Jieyu capsule. The degree of depression and quality of life before and after treatment were evaluated by Hamilton Depression Rating Scale (QOLIE-31) and Quality of Life Scale (QOLIE-31), and the frequency of seizures and adverse reactions before and after treatment were compared. Results After 3 months of treatment, the HAMD score and seizure frequency of study group were significantly lower than those of control group (P <0.01), QOLIE-31 score was significantly higher than that of control group (P <0.01), adverse reactions No statistical difference (P> 0.05). Conclusion Shugan Jieyu Capsule can effectively reduce the symptoms of depression in patients with epilepsy, reduce the number of seizures, and has high safety.