论文部分内容阅读
据近期出版的美国《癌症研究》杂志报道,圣裘得儿童研究医院的科学家们将小鼠脑肿瘤细胞的细胞核敲除,然后移植到自身细胞核已被除去的小鼠卵细胞中,即使引起癌症的突变仍然存在,但仍能够培育出组织正常的克隆胚胎。该项研究的负责人、来自于圣裘得儿童研究医院发育神经生物学科的James Morgan博士指出,该研究发现证实癌变状态可通过改造使引起癌症的遗传物质逆转;此外,研究还显示单单遗传突变并不足以导致细胞发生癌变。需特别强调的是,所谓的表遗传因素才是肿瘤发育和维持的关键因素。表遗传因素是指那些影响
According to a recent issue of the Journal of Cancer Research in the United States, Scientists at San Joaquin Children’s Research Hospital knocked out the nuclei of mouse brain tumor cells and transplanted them into mouse egg cells where their nuclei had been removed, even though it caused cancer The mutation is still present, but it is still able to breed normal cloned embryos. The study, led by James Morgan, PhD, developmental neurobiology at San Joan Childrens Research Hospital, said the study found that confirming that cancerous conditions can be reversed by reversing the genetic material that causes the cancer. In addition, the study also showed that single genetic mutations Not enough to cause cancer cells. Of particular note is that the so-called epigenetic elements of the tumor is the key factor in tumor development and maintenance. Table genetic factors are those effects