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系统性红斑狼疮(SLE)是非器官特异的自身免疫性疾病。近年来发现SLE的发病是由于患者免疫调节功能紊乱导致多种自身抗体形成和多器官损害。其中抗淋巴细胞抗体又与某类免疫调节细胞的缺失或异常有关,如CD4和CD8表型细胞的缺失或异常导致CD4~+/CD8~+细胞比例失调,HLA-DR~+CD4~+辅助/诱导T细胞选择性增加和CD4~+2H4~+和CD4~+4B4~+T细胞亚群的变化以及带CD8~+VV~+表型的反抑制T细胞(Tcs)增加导致免疫抑制功能减退,B细胞功能亢进,从而更促使自身抗体的产生;抗淋巴细胞抗体又与免疫系统的无能有关,如它能抑制T细胞的增殖和淋巴因子的诱导。因此,SLE免疫调节功能紊乱可能是由于T细胞亚群失衡和抗淋巴细胞抗体所引起。
SLE is a non-organ-specific autoimmune disease. In recent years, the incidence of SLE was found to be due to a variety of autoantibodies and multiple organ damage caused by dysfunction of immune regulation in patients. Among them, the anti-lymphocyte antibodies are related to the deletion or abnormality of certain types of immunoregulatory cells. For example, the deletion or abnormality of CD4 and CD8 phenotype cells leads to the imbalance of CD4 ~ + / CD8 ~ + cells and the HLA-DR ~ + CD4 ~ + / Induction of T-Cell Selective Increase and Changes in CD4 ~ + 2H4 ~ + and CD4 ~ + 4B4 ~ + T Cell Subsets as Well as Increased Anti-Trk T cells with CD8 ~ + VV ~ + Phenotypes Cause Immune Suppression Decreased, B cell hyperthyroidism, which led to the production of autoantibodies; anti-lymphocyte antibodies and immune system incompetence, as it can inhibit T cell proliferation and lymphokine induction. Therefore, SLE immunomodulatory dysfunction may be due to imbalance of T cell subsets and anti-lymphocyte antibodies.