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免疫损伤的患者可以发生严重的局限性或播散性的粘膜和皮肤上单纯疱疹病毒感染。1978年以来从细胞培养与实验动物中发现无环鸟甙(acyclo-vir,acycloquanosine)能有效地抑制单纯疱疹病毒。Selby 等在1979年报道了23例有单纯疱疹或带状疱疹病毒感染的肿瘤病人,从静脉给予无环鸟甙治疗,取得良效。本文作者报道24例因免疫损伤而得粘膜皮肤单纯疱疹病毒感染的患者。用随机抽样和双盲法,用无环鸟甙和安慰剂对照治疗,其中11名用无环鸟甙,13名用安慰剂,结果无环鸟甙有明显疗效。
Serious limitations or disseminated herpes simplex virus infection on mucous membranes and skin can occur in immunocompromised patients. Since 1978, acyclo-vir (acycloquanosine) was found to be effective in inhibiting herpes simplex virus from cell culture and laboratory animals. Selby et al reported in 1979, 23 cases of patients with herpes simplex or herpes zoster virus in patients with tumor, intravenous administration of acyclovir, made good. The authors report 24 patients with mucosal skin herpes simplex virus infection due to immune damage. Randomized and double-blind treatment with acyclovir and placebo control treatment, of which 11 acyclovir, 13 with placebo, the results of acyclovir significant effect.