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应用免疫组织化学方法对59例膀胱移行细胞癌中抑癌基因P16及P53的表达进行研究，结果显示：59例膀胱移行细胞癌中P16及P53基因的阳性表达率分别为47.46％和54．24％。P16及P53基因在膀胱移行细胞癌中的阳性表达率在肿瘤病理分级及临床分期等方面分别具有显著性差异（P＜0．05），且P16及P53基因表达之间具有显著相关性（P＜0．05）。提示P16及P53基因的异常表达在膀胱肿瘤的发展过程中起重要作用;P53基因可能对P16基因的表达起调节作用。
Immunohistochemistry was used to study the expression of tumor suppressor genes P16 and P53 in 59 cases of bladder transitional cell carcinoma. The positive rates of P16 and P53 in 59 cases of transitional cell carcinoma of the bladder were 47.46% and 54.24 %. The positive rates of P16 and P53 in transitional cell carcinoma of the bladder were significantly different (P <0.05), and the expression of P16 and P53 was significantly correlated with the pathological grade and clinical stage (P <0.05) <0.05). It is suggested that the abnormal expression of P16 and P53 plays an important role in the development of bladder tumor. P53 gene may play a regulatory role in the expression of P16 gene.