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目的：探讨不育男性精浆四种肿瘤标志物与不育之间关系。方法：用ELISA法测定了42例不育男性精浆和血清内的前列腺特异抗原（PSA）、卵巢癌抗原（CA125）、乳腺癌抗原（CA15－3）、胃肠癌抗原（CA19－9）的浓度，并与精子密度、精液液化正常者进行比较。结果：所检测的四种肿瘤标志物精浆浓度明显高于血清浓度，但与精子的运动特性均无明显相关；无精子者精浆内CA19－9浓度明显高于精子密度正常者（P＜0．05）．精液液化不良者精浆内PSA浓度显著低于精液液化正常者（P＜0．01）。结论：提示精浆内CA19－9、PSA与生殖活动有一定关系，有进一步深入研究的必要。
Objective: To investigate the relationship between four tumor markers and infertility in infertile male seminal plasma. Methods: PSA, CA125, CA15-3 and CA19-9 were determined in 42 cases of infertile male seminal plasma and serum by ELISA method. Of the concentration, and with sperm density, semen liquefaction were normal. Results: The seminal plasma concentrations of the four tumor markers detected were significantly higher than those of the serum but not related to the sperm motility. The concentration of CA19-9 in seminal plasma of spermatozoa was significantly higher than that of normal sperm (P < 0.05). Semen liquefaction in patients with seminal plasma PSA concentration was significantly lower than normal semen liquefaction (P <0.01). Conclusion: It is suggested that there is a relationship between PSA and reproductive activities in seminal plasma, which may be necessary for further study.