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目的 :检测恶性肿瘤血清中癌相关抗原 ( CA19-9、CA2 4-2、CA15-3 ) ,以及恶性肿瘤特异性生长因子 ( TSGF)。评价其对恶性肿瘤的诊断、病情监测和预后判断的价值。方法 :检测 158例恶性肿瘤及 3 0名健康人血清中 CA19-9、CA2 4-2、CA15-3、TSGF的含量。结果 :TSGF在全部恶性肿瘤组中含量与正常对照组比较均有非常显著差异 ( P<0 .0 0 1) ,TSGF在全部恶性肿瘤组的阳性率为 85.4%。肝癌、胰腺癌、肠癌、肺癌组中 CA19-9、CA2 4-2与正常对照组比较有非常显著差异 ( P<0 .0 1～ 0 .0 0 1) ,CA19-9+ CA2 4-2 + TSGF的敏感性及准确性均较单项检测高。 CA15-3在乳腺癌组中阳性率较高为 57.7% ,在肺癌组也有较高的阳性率 ( 4 7.1% ) ,与正常对照组比较有非常显著差异 ( P<0 .0 1～ 0 .0 0 1) ,CA15-3 + TSGF的敏感性及准确性较 CA15-3单项检测高。结论 :血清肿瘤标志物的单独检测对某些肿瘤有显著意义 ,而联合检测应是临床发展的方向 ,对恶性肿瘤的早期诊断及病情监测有重要价值。
Objective: To detect the serum levels of cancer-associated antigens (CA19-9, CA2 4-2, CA15-3) and malignant tumor-specific growth factor (TSGF) in malignant tumors. Evaluate the value of its diagnosis of malignant tumors, disease monitoring and prognosis. Methods: The serum contents of CA19-9, CA2 4-2, CA15-3 and TSGF in 158 malignant tumors and 30 normal controls were detected. Results: The content of TSGF in all malignant tumors was significantly higher than that in normal controls (P <0.01). The positive rate of TSGF in all malignant tumors was 85.4%. The levels of CA19-9 and CA2 4-2 in liver cancer, pancreatic cancer, intestinal cancer and lung cancer group were significantly different from those in normal control group (P <0.01 ~ 0.010), CA19-9 + CA2 4- 2 + TSGF sensitivity and accuracy were higher than the single test. The positive rate of CA15-3 in breast cancer was 57.7%, and it was higher in lung cancer (4.71%) than that in normal controls (P <0.01 ~ 0. 0 0 1). The sensitivity and accuracy of CA15-3 + TSGF were higher than those of CA15-3 alone. Conclusion: The detection of serum tumor markers alone has certain significance for some tumors, and the combined detection should be the direction of clinical development, which is of great value in the early diagnosis and condition monitoring of malignant tumors.