【摘 要】
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OBJEVTIVE:To investigate the effects of Cyclo-carya paliurus (C.paliurus) polysaccharides on the spleen injury of diabetic rats.METHODS.:Animals were divided into 6 groups,in-cluding normal group,model group,control group,low-dose group of C.paliurus poly
【机 构】
：
Medical College,Pingdingshan University,Pingdingshan 467000,China;College of Chem-istry and Chemical
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OBJEVTIVE:To investigate the effects of Cyclo-carya paliurus (C.paliurus) polysaccharides on the spleen injury of diabetic rats.METHODS.:Animals were divided into 6 groups,in-cluding normal group,model group,control group,low-dose group of C.paliurus polysaccharides treat-ment,middle-dose group of C.paliurus polysaccha-rides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7 (IL-7) and IL-10 were measured by en-zyme-linked immunosorbent assay.RESULTS:Compared with that of model group,su-peroxide dismutase,catalase,glutathione peroxi-dase,glutathione reductase level increased 78.63％(P ＜ 0.05),51.76％ (P ＜ 0.05),2.95 times (P ＜ 0.01)and 41.11％ (P ＜ 0.05) in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66 (P ＜ 0.01) and 1.21 times (P ＜ 0.01) in the high-dose group of C.pali-urus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus poly-saccharides may play a protecting role for spleen in-jury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity.
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