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目的探讨雷尼替丁联合奥美拉唑治疗胃食管反流症的临床疗效。方法选取横县人民医院消化内科门诊2013年11月—2016年11月收治的胃食管反流症患者150例,根据双盲原则随机分为对照组和试验组,各75例。患者入院后均给予常规对症治疗,对照组患者给予雷尼替丁治疗,试验组患者在对照组基础上给予奥美拉唑治疗,两组患者均以4~8周为1个治疗疗程。比较两组患者的临床疗效及不良反应发生情况。结果试验组患者临床疗效优于对照组(P<0.05)。试验组患者不良反应发生率低于对照组(P<0.05)。结论采用奥美拉唑联合雷尼替丁治疗胃肠道反流症的临床疗效优于雷尼替丁单独治疗,可明显改善患者的临床症状及体征,且安全性好。
Objective To investigate the clinical efficacy of ranitidine combined with omeprazole in the treatment of gastroesophageal reflux disease. Methods 150 patients with gastroesophageal reflux disease admitted from November 2013 to November 2016 in Hengdian People ’s Hospital Department of Gastroenterology were randomly divided into control group and experimental group according to the principle of double - blind, with 75 cases in each group. All patients were given conventional symptomatic treatment after admission. Patients in the control group were treated with ranitidine. Patients in the test group were treated with omeprazole on the basis of the control group. Both groups were treated with 4 to 8 weeks of treatment. The clinical efficacy and adverse reactions of the two groups were compared. Results The clinical efficacy of the experimental group was better than that of the control group (P <0.05). The incidence of adverse reactions in the experimental group was lower than that in the control group (P <0.05). Conclusion Omeprazole combined with ranitidine in the treatment of gastrointestinal reflux disease is superior to ranitidine alone in treatment of clinical symptoms, can significantly improve the clinical symptoms and signs of patients with good safety.