【摘 要】
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A series of retinoate and retinamide derivatives were designed,synthesized,and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry as
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
A series of retinoate and retinamide derivatives were designed,synthesized,and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays(FCM).All compounds showed cytotoxicity,especially compounds 1a and 1d exhibited a higher cytotoxicity than other derivatives and all-trans retinoic acid(ATRA).Furthermore,compound 1d could induce NB4 cell lines differentiation efficiently.
A series of retinoate and retinamide derivatives were designed, synthesized, and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays (FCM). All compounds showed cytotoxicity, especially compounds 1a and 1d exhibited a higher cytotoxicity than other derivatives and all-trans retinoic acid (ATRA) .Furthermore, compound 1d could induce NB4 cell lines differentiation efficiently.
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