目的　观察博宁与化疗联用治疗 40例骨转移癌患者的临床疗效。方法　在化疗前及化疗间歇期应用博宁 ,博宁首剂 90毫克 +生理盐水 5 0 0毫升静脉滴注 ,4～ 6小时滴完 ,2周后加用博宁 30毫克 +生理盐水 5 0 0毫升静脉滴注 ,4～ 6小时滴完 ,1个月为一个疗程 ,两个疗程后评价疗效。结果　用博宁联合化疗治疗骨转移癌患者疼痛的有效率为 82 .5 %,活动能力改善的有效率为 70 .0 %。博宁的不良反应主要为发热及轻度恶心等 ,对症治疗后均可改善。结论　博宁联合化疗治疗骨转移癌患者的疼痛安全有效 ,并可改善患者的活动能力。 Objective To observe the clinical efficacy of Boning combined with chemotherapy in the treatment of 40 patients with bone metastases. Methods Before the chemotherapy and intermittent chemotherapy use Bonin, Boning first dose of 90 mg + saline 500 ml intravenously drip 4 to 6 hours after 2 weeks with Bonin 30 mg + saline 50 0 ml intravenous drip, 4 to 6 hours drip finished, 1 month for a course of treatment, evaluation of the efficacy of two courses. Results Boning combined with chemotherapy for the treatment of pain in patients with bone metastases effective rate was 82.5%, the improvement of mobility was 70.0%. Bonin’s adverse reactions are mainly fever and mild nausea, symptomatic treatment can be improved. Conclusion Bonin combined with chemotherapy for the treatment of patients with bone metastases of pain is safe and effective, and can improve the patient’s mobility.