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本文用放射免疫分析法(RIA),对35例健康人及60例慢性肾脏疾病患者,进行了血、尿β_2-微球蛋白(β_2-M)、尿Tamm-Horsfall蛋白(尿THP)及尿白蛋白(尿Alb)的联合检测。结果表明,除肾盂肾炎组血β_2-M无明显改变外(p>0.05),其余各肾脏疾病组血、尿β_2-M和尿Alb均明显增高(p均<0.05);除肾病综合征组尿THP增高外(p<0.05),其余各组尿THP均降低(p<0.05);血、尿β_2-M、尿THP与肾功能密切相关。联合检测这四项指标,能更早期、灵敏、准确、综合的判断肾小球-小管功能的改变。
Radioimmunoassay (RIA) was used in this study. Serum and urinary β_2-microglobulin (β_2-M), urinary Tamm-Horsfall protein (urinary THP) and urine in 35 healthy people and 60 patients with chronic kidney disease Albumin (urine Alb) joint detection. The results showed that except for pyelonephritis group, there was no significant change in blood β_2-M (p> 0.05), and the levels of blood and urine β_2-M and urinary Alb in other renal disease groups were significantly increased (all P <0.05). In addition to nephrotic syndrome group (P <0.05), while the other groups had lower THP (p <0.05). Serum and urinary β_2-M and urine THP were closely related to renal function. Joint detection of these four indicators, more early, sensitive, accurate, comprehensive judgment glomerular - tubular function changes.