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目的:探讨微小染色体维持蛋白5(MCM5)在大肠癌组织中的表达及其意义。方法:应用免疫组化SP法检测31例正常大肠组织、60例大肠癌组织中的MCM5的表达。结果:MCM5高表达于大肠癌细胞核,大肠癌组织中MCM5表达率为63.3%(38/60);正常大肠组织中MCM5表达率3.2%(1/31),(P<0.05);MCM5在大肠癌中的表达与肿瘤的Dukes分期、淋巴结转移、组织分型相关(P<0.05)。结论:MCM5可作为新的大肠癌增殖标志物。
Objective: To investigate the expression of minichromosome maintenance protein 5 (MCM5) in colorectal carcinoma and its significance. Methods: Immunohistochemical SP method was used to detect the expression of MCM5 in 31 cases of normal colorectal tissues and 60 cases of colorectal carcinomas. Results: MCM5 was highly expressed in the nucleus of colorectal cancer, the expression rate of MCM5 was 63.3% (38/60) in colorectal carcinoma, MCM5 was 3.2% (1/31) in normal colorectal tissues (P <0.05) The expression of cancer correlated with Dukes stage, lymph node metastasis and histological type (P <0.05). Conclusion: MCM5 can be used as a new marker of colorectal cancer proliferation.