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目的比较头孢曲松、头孢噻肟、头孢呋辛治疗下呼吸道轻中度感染的疗效和安全性。方法在５家大型教学医院进行多中心、前瞻性、随机比较。头孢曲松组（Ａ组）４８例１ｇ／ｄ，头孢噻肟组（Ｂ组）４６例３ｇ／ｄ和头孢呋辛组（Ｃ组）４８例２２５ｇ／ｄ，疗程为７天。均静脉注射，３组１４２例患者，年龄１８～７０岁。一般资料相似（Ｐ＞０．０５）。结果３组临床疗效差异无显著性（Ｐ＞０．０５），分别为８１％、８３％、７９％。细菌阳性率为４５％（６４／１４２），细菌清除率分别为８０％、７８％、７５％，３组在统计学上差异无显著性（Ｐ＞０．０５）。３组患者在用药过程中无一例出现皮疹及其它副作用。结论在治疗轻中度下呼吸道感染中，１ｇ头孢曲松、３ｇ头孢噻肟和２２５ｇ头孢呋辛都是安全和有效的，且１周的疗程也是足够的。但在治疗这些疾病时，１ｇ头孢曲松更为方便
Objective To compare the efficacy and safety of ceftriaxone, cefotaxime and cefuroxime in the treatment of mild and moderate infections of lower respiratory tract. Methods A multicenter, prospective, randomized comparison of five major teaching hospitals. 48 cases in ceftriaxone group (group A), 2 cases in cefotaxime group (group B), 46 cases in group cefotaxime (group B) and 48 cases in group Cefuroxime (group C), 225 g / day for 7 days. All intravenous injection, 142 patients in 3 groups, aged 18 to 70 years. General information is similar (P> 0.05). Results There was no significant difference in clinical efficacy between the three groups (P> 0.05), which were 81%, 83% and 79% respectively. The positive rate of bacteria was 45% (64/142), and the bacterial clearance rates were 80%, 78% and 75% respectively. There was no significant difference among the three groups (P> 0.05). None of the three groups developed rashes and other side effects during the course of medication. Conclusions Ceftriaxone 1 g, cefotaxime 3 g and cefuroxime 2.25 g are safe and effective in the treatment of mild to moderate lower respiratory tract infections, and a one-week course of treatment is sufficient. But in the treatment of these diseases, 1g ceftriaxone more convenient