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目的 :研究盐酸多虑平在不同扩散膜上的透皮扩散情况以及透皮扩散促进剂氮酮 (azone)对其扩散的影响。方法 :使用流通扩散池模型 ,分别以蛇蜕和小鼠皮为扩散膜 ,研究 5 %的盐酸多虑平在加入 azone和不加 azone的情况下的透皮扩散强度。结果 :不加 azone的经皮穿透系数鼠皮是蛇蜕的 8倍 ,azone对蛇蜕的穿透系数可提高 1.7倍。对鼠皮仅增加 0 .3倍。结论 :盐酸多虑平经鼠皮的穿透系数明显高于蛇蜕 (P <0 .0 1) ,azone对蛇蜕的促透作用较鼠皮更强
Objective: To study the transdermal diffusion of doxepin in different diffusion films and the effect of azone, a transdermal diffusion accelerator, on its diffusion. Methods: The flow diffusion model was used to study the transdermal diffusion of 5% doxepin in the presence of azone and azone, respectively, using snake slough and mouse skin as diffusion membrane. Results: Percutaneous penetration coefficient rat skin without azone was 8 times that of snake slides, azone permeability coefficient of snake slides could be increased by 1.7 times. The mouse skin increased by only 0.3 times. CONCLUSION: The penetration coefficient of doxepin hydrochloride in rat skin is significantly higher than that in snake slough (P <0.01), azone is more permeable than snake skin