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目的分析高分化黏液表皮样癌的适当治疗原则和方法与预后的相关性。方法对1991—2006年在我院治疗的21例高分化黏液表皮样癌患者的临床资料进行回顾分析,分析适当的治疗方法及影响预后的因素。结果 21例患者均经过手术治疗,5年生存率为90.5%,术后有5例复发,其中1例Ⅳ期患者术后远处转移死亡、1例Ⅱ期患者因术中肿瘤破裂黏液溢出导致术后复发而未再接受治疗于术后4.5年死亡、3例经再次手术治疗后痊愈。结论高分化黏液表皮样癌手术治疗后5年生存率较高,手术切缘癌细胞阳性是影响预后的重要因素;建议对肿瘤临床分期高、存在淋巴结转移、手术切除范围不足致切缘癌细胞阳性者术后放疗。
Objective To analyze the relationship between the appropriate treatment principles and methods and prognosis of well-differentiated mucoepidermoid carcinoma. Methods The clinical data of 21 patients with well-differentiated mucoepidermoid carcinoma treated in our hospital from 1991 to 2006 were retrospectively analyzed, and the appropriate treatment methods and prognostic factors were analyzed. Results All the 21 patients were surgically treated. The 5-year survival rate was 90.5%. Five patients had recurrence after operation. One patient with stage Ⅳ disease died of distant metastasis and one patient with stage Ⅱ disease caused by tumor rupture mucus overflow Recurrence without recurrence of postoperative recurrence in 4.5 years after the death, 3 cases recovered after re-operation. Conclusions The 5-year survival rate of the well-differentiated mucinous epidermoid carcinoma after surgery is high, and the positive of the surgical margin cancer cells is an important factor affecting the prognosis. It is suggested that the clinical stage of the tumor is high with lymph node metastasis, Positive postoperative radiotherapy.