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目的探讨人类白细胞抗原-E(human leukcocyte antigen-E,HLA-E)在子疒间前期(preeclampsia,PE)发病机制中的作用及预测价值。方法轻度PE患者20例(轻度PE组),重度PE患者20例(重度PE组),正常分娩孕妇20例(对照组),3组采用ELISA法检测孕中期与孕晚期血清HLA-E表达情况,采用RT-PCR方法检测胎盘中HLA-E mRNA表达情况。结果轻度PE组与重度PE组孕中期、晚期血清HLA-E水平及胎盘HLA-E mRNA水平明显低于对照组(P<0.05),重度PE组低于轻度PE组,但差异无统计学意义(P>0.05);3组孕晚期血清HLA-E水平均高于孕中期(P<0.05)。结论 PE患者孕中期出现HLA-E表达降低可能对PE的预测有一定价值。
Objective To investigate the role and predictive value of human leukocyte antigen-E (HLA-E) in the pathogenesis of preeclampsia (PE). Methods Twenty patients with mild PE (mild PE group), 20 patients with severe PE (severe PE group) and 20 normal pregnant women (control group) were enrolled in this study. The serum levels of HLA-E The expression of HLA-E mRNA in the placenta was detected by RT-PCR. Results The levels of HLA-E and HLA-E mRNA in the second trimester and the second trimester in the mild and severe PE groups were significantly lower than those in the control group (P <0.05), while those in the severe PE group were lower than those in the mild PE group (P> 0.05). Serum HLA-E levels in the third trimester of pregnancy were higher than those in the second trimester (P <0.05). Conclusions The decrease of HLA-E expression in the second trimester of PE patients may have certain value in predicting PE.