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目的调查蒙古族农牧民C反应蛋白(CRP)水平和代谢综合征(MS)组分及其聚集性之间的关联性。方法采用现况研究的方法对内蒙古通辽市农牧区2 536名20岁以上的蒙古族居民进行生活方式危险因素、体质、身高、腰围、臀围、血压、空腹血糖、血脂和CRP的调查和检测。对蒙古族农牧区居民CRP水平与MS组分聚集作用的患病危险性进行分析,采用有序多分类的非条件Logistic回归分析模型,计算出MS组分的不同暴露组合下的患病危险性,即OR值及其95%CI。结果代谢综合征年龄性别标化患病率是17.1%,男性(11.4%)低于女性(21.6%)(P<0.01)。按CRP四等分位划分为4个等级,同时根据代谢综合征组分聚集的个数分组(0,1,2,3,4,5个代谢综合征组分)。在5个单因素及5个多因素Logistic回归模型中,4级CRP水平与代谢综合征每个组分均有关联(均P<0.01)。有序多分类Logistic回归分析结果表明:调整性别、年龄、总胆固醇、低密度脂蛋白胆固醇后,3级和4级CRP水平与聚集一个及一个以上代谢综合征组分的危险性是1级的2.35(1.91～2.89)和6.87(5.50～8.57)倍。代谢综合征组分积累(增加一个或一个以上组分)的危险性随着CRP等级的增加而增加(趋势性检验,P<0.01)。结论 CRP水平增加和代谢综合征单个组分及其组分的聚集性有连续、独立的显著关联。
Objective To investigate the association between Mongolian herdsman’s C-reactive protein (CRP) level and metabolic syndrome (MS) components and their aggregation. Methods The present study investigated the lifestyle risk factors, body constitution, height, waist circumference, hip circumference, blood pressure, fasting blood glucose, blood lipids and CRP in 2 536 Mongolian residents over 20 years of age in Tongliao City, Inner Mongolia Detection. To analyze the prevalence of CRP levels and the accumulation of MS components among Mongolian people in pastoral areas and to evaluate the prevalence of MS under different exposure combinations using an ordered and multi-category non-conditional logistic regression model Sex, namely OR value and its 95% CI. Results The age-standardized rate of metabolic syndrome was 17.1%, while that of males (11.4%) was lower than that of females (21.6%) (P <0.01). According to the CRP quartiles divided into four levels, according to the number of metabolic syndrome component aggregation (0,1,2,3,4,5 metabolic syndrome components). In 5 single factor and 5 multivariate logistic regression models, level 4 CRP was associated with each component of metabolic syndrome (all P <0.01). Logistic regression analysis showed that the levels of grade 3 and 4 CRP and the risk of accumulating one or more components of metabolic syndrome were adjusted to be level 1 after adjustment for sex, age, total cholesterol, and low-density lipoprotein cholesterol 2.35 (1.91 ~ 2.89) and 6.87 (5.50 ~ 8.57) times. The risk of accumulation of metabolic syndrome components (one or more components increased) increased with CRP levels (trend test, P <0.01). Conclusion There is a continuous and independent association between the increase of CRP level and the aggregation of individual components and their components in metabolic syndrome.