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目的 :研究H2 受体拮抗剂 (H2 RA)三联疗法与质子泵抑制剂 (PPI)三联疗法及其 1周与 2周疗法对根除幽门螺杆菌 (H .pylori,Hp)的效果。 方法 :1 2 8例Hp阳性的胃炎和十二指肠溃疡患者随机分成H2 RA三联组和PPI三联组。H2 RA三联组 (法莫替丁 2 0mg ,bid +阿莫西林 1 .0g,bid +甲硝唑 0 .4g ,bid ,疗程 1或 2周 ) ,PPI三联组 (奥美拉唑 2 0mg ,bid +阿莫西林 1 .0 g ,bid +甲硝唑 0 .4g ,bid ,疗程 1或 2周 )。疗程结束后 4周复查Hp。 结果 :H2 RA三联与PPI三联疗法Hp根除率 1周分别为 56 .0 %和 76 .9% ;2周为 81 .6 %和 82 .1 %。 结论 :H2 RA三联疗法 2周的Hp根除率明显高于 1周Hp根除率 (P <0 .0 5) ,但PPI三联疗法 1周与 2周无统计学差异 (P >0 .0 5)。H2 RA三联疗法与PPI三联疗法的Hp根除率无统计学差异
OBJECTIVE: To study the effect of H2 receptor antagonist (H2RA) triple therapy and proton pump inhibitor (PPI) triple therapy and its 1-week and 2-week therapy on H. pylori eradication. Methods: One hundred and eighty-eight patients with Hp-positive gastritis and duodenal ulcer were randomly divided into H2 RA triad and PPI triad. H2 RA triple group (famotidine 20mg, bid + amoxicillin 1.0g, bid + metronidazole 0.4g, bid, course of treatment for 1 or 2 weeks), PPI triple group (omeprazole 20mg, bid + amoxicillin 1.0 g, bid + metronidazole 0.4g, bid, course of treatment for 1 or 2 weeks). 4 weeks after the end of treatment review Hp. Results: Hp eradication rates were 56.0% and 76.9% for H2 RA triple therapy and PPI triple therapy respectively, 81.6% and 82.1% for 2 weeks. Conclusions: The Hp eradication rate of H2-RA triple therapy group was significantly higher than that of 1-week Hp eradication group (P <0.05), but there was no significant difference between PPI triple therapy group and control group (P> 0.05) . There was no significant difference in Hp eradication rates between H2RA triple therapy and PPI triple therapy