用放射配体结合分析法动态观察了高选择性β_2-激动剂特普他林对豚鼠肺组织β受体的调节过程。正常豚鼠分别肌注不同天数的特普他林0.2mg/kg·次,3次/d。用药3天后,豚鼠肺组织β受体开始发生向下调节,停药3天后,肺组织β受体恢复正常。本实验结果为临床合理应用β-激动剂提供了必要的实验依据。 Radioligand binding assay was used to dynamically observe the regulation of β receptor in the lung tissue of guinea pigs with high selective beta 2-agonist. Normal guinea pigs were intramuscularly injected with different days of terbutaline 0.2mg / kg · times, 3 times / d. After 3 days of treatment, the β receptor in the lung tissue of guinea pigs began to down-regulate. After 3 days of withdrawal, the β receptor in the lung tissue returned to normal. The results of this experiment provide the necessary experimental basis for the rational application of beta-agonists.