系统性红斑狼疮(SLE)是一种典型的人类自身免疫性疾病。这种病的特点是能产生DNA的抗体,染色体不稳定,DNA修复机能较弱;在这种病人的血清中有能导致正常人淋巴细胞染色体断裂和姐妹染色单体交换(SCE)的断裂因子。现在对这种因子和SCE形成的机理还不太了解。只知道它与染色体的不稳定性有关,并知道O_2~-和超氧化物歧化酶也与这因子有关。对遗传损伤较敏感的一些疾病测定了SCE的频率,结果表 SLE is a classic human autoimmune disease. The disease is characterized by antibodies that produce DNA, chromosomal instability, and weakening of DNA repair functions. In this patient’s serum there is a rupture factor that causes normal human lymphocyte chromosome rupture and sister chromatid exchange (SCE) . The mechanism by which such a factor and SCE are formed is not well understood. Only know it with the chromosome instability, and know O_2 ~ - and superoxide dismutase also with this factor. Some diseases that are more susceptible to genetic damage determine the frequency of SCE, the results table