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近年来,应用抗血清的研究证明,内源性阿片样物质(endogenous opiate like substance简写OLS)对血压可能具有生理性调节作用。OLS对血压的调节主要是通过中枢的作用来完成的。并认为脑内OLS至少有二个起着相反作用的功能系统,即脑啡肽升压系统和β-内啡肽降压系统。β-内啡肽降压系统的降压作用可能与在中枢神经系统中孤束核水平上,减压反射的接通有关。在高血压病人和高血压的动物模型中,发现痛阈升高并且血浆和脑内脑啡肽活性升高。提示OLS可能参与高血压的发病机制。但在休克时OLS大量释放,使血压持续下降。阿片受体的特异性受体阻断剂—纳洛酮,则使血压回升,并可选择性地增加休克时心、脑血流量。目前,国外亦有用纳洛酮来抢救各种类型的休克。无疑,OLS与血压关系的研究具有重要的临床价值。
In recent years, studies using antisera have proved that endogenous opioids (OLS) may have a physiologic regulatory effect on blood pressure. OLS regulation of blood pressure is mainly done through the role of the center. And that at least two brain OLS have the opposite effect of the functional systems, namely, the enkephalin-stress system and β-endorphin antihypertensive system. The hypotensive effect of the β-endorphin hypotensive system may be related to the turn-on of decompressive reflex in the solitary nucleus of the central nervous system. In animal models of hypertension and hypertension, pain thresholds have been found to be elevated and enkephalin activity in plasma and brain has been increased. Suggesting that OLS may be involved in the pathogenesis of hypertension. However, a large number of OLS release in shock, so that blood pressure continued to decline. Naloxone, a specific receptor blocker of opioid receptors, increases blood pressure and selectively increases heart and cerebral blood flow during shock. At present, foreign countries also use naloxone to rescue various types of shock. Undoubtedly, OLS and blood pressure research has important clinical value.