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几十年来,对于妊娠期的母体与胎体双方的形态学与生理学变化,已进行了较为充分的研究。但是,机体如何使母、胎这两个免疫不相容性个体共存的基本原理仍然不清。这种高成功率的自然移植的奇异现象有待解释,最近的研究资料提示。由存在于潜在免疫排斥部位的某些可溶性因子介导的母体免疫抑制,是母胎共存的重要机制。不久前发现的妊娠相关血浆蛋白(PAPP-A)可能就是这种免疫抑制因子。
For decades, both the morphological and physiological changes in both mother and carcass during pregnancy have been studied more fully. However, the rationale for how the body coexists with both immunocompromised individuals, mothers and fetuses, remains unclear. The singularity of this high rate of natural grafting remains to be explained, as recent research suggests. Maternal immunosuppression mediated by certain soluble factors present at sites of potential immune rejection is an important mechanism for the coexistence of maternal and fetal tissues. The pregnancy-associated plasma protein (PAPP-A) that was discovered not long ago may be such an immunosuppressive factor.