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干扰素治疗慢性乙型肝炎病毒感染有效,用定量聚合酶链反应(PCR)检测乙型肝炎病毒DNA(HBV DNA)有助于了解干扰素治疗HBV感染情况。作者连续测定10名有持续应答的患者在治疗期间(平均6个月)和治疗后18个月中的血清标本。这10名患者抗-HBe均为阳性,其中5例HBsAg阴性而抗HBs为阳性。以12名非应答病人作为对照。用标准杂交试验和定量PCR检测血清HBV DNA。治
Interferon treatment of chronic hepatitis B virus infection effective, quantitative polymerase chain reaction (PCR) detection of hepatitis B virus DNA (HBV DNA) help to understand the interferon treatment of HBV infection. The authors continually measured serum samples from 10 patients with a sustained response during treatment (mean 6 months) and 18 months after treatment. Anti-HBe was positive in all 10 patients, of which 5 were negative for HBsAg and positive for anti-HBs. Twelve non-responders were used as controls. Serum HBV DNA was detected by standard hybridization and quantitative PCR. rule