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催醒宁是由依色林衍化来的一个新胆碱酯酶抑制剂,用在中药麻醉病人手术后催醒,病人醒得快,副作用小,一次用药可维持5—6小时,比依色林安全,已在临床应用。为了确保安全,深入了解其药理性质,必须研究其在体内的代谢规律。首先要解决分析方法,由于催醒宁毒性大,用药剂量小,所以要求方法灵敏度高。本文介绍用萤光分析方法,灵敏度可达10~(-8)克/毫升,可以满足要求。
Reminder Ning is a new cholinesterase inhibitor derived from Yi Silin, used in Chinese medicine anesthesia patients wake up after surgery, the patient woke up fast, side effects, a medication can be maintained for 5-6 hours, than the ezrin Safe, already in clinical application. In order to ensure safety and understand its pharmacological properties, we must study its metabolism in the body. First of all, to solve the analytical method, due to reminder rather toxicity, drug dosage is small, so the method requires high sensitivity. This article describes the use of fluorescence analysis, the sensitivity of up to 10 ~ (-8) g / ml, to meet the requirements.