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离子迁移率的非线性函数反映了物质本身的微观碰撞特性,是FAIMS技术实现离子分离检测的基础。现有的离子迁移率非线性函数求解方法多是近似求解,存在较大误差。该工作提出了一种基于半正弦分离电压和FAIMS谱图峰位置下的严格求解方法,推导出严格的二阶、四阶系数求解方程。利用自制的高场不对称波形离子迁移谱仪分别对乙醇、间二甲苯和正丁醇三种典型的醇和苯类物质进行检测,获取了三种物质的FAIMS谱图,通过谱图峰位置获得了不同分离电压值下的补偿电压,利用最小二乘法求出三种离子非线性函数二阶、四阶系数。拟合后的均方误差表明FAIMS非线性函数严格求解的方法,明显优于现有的求解方法。有助于提高FAIMS检测分辨率,进而有助于建立更加准确的FAIMS图谱,实现FAIMS对检测物质的精准识别。
The nonlinear function of ion mobility reflects the microscopic collision characteristics of the material itself and is the basis of the FAIMS technology for ion separation detection. Existing methods for solving the nonlinear function of ion mobility are mostly approximate solutions, and there is a big error. This work proposed a strict solution method based on the half-sine separation voltage and the peak position of the FAIMS spectrum, and derived the strict second-order and fourth-order coefficient solving equations. Three kinds of typical alcohols such as ethanol, m-xylene and n-butanol and benzene were detected by home-made high-field asymmetric waveform ion mobility spectrometer. The FAIMS spectra of three substances were obtained and the peak positions of the spectra were obtained Different voltage values under the separation of the compensation voltage, the use of least squares method to obtain three kinds of ion nonlinear function of the second-order, fourth-order coefficients. The mean square error after fitting shows that the method of strictly solving the nonlinear function of FAIMS is obviously better than the existing solving method. Which can help to improve the resolution of FAIMS detection and help to establish a more accurate FAIMS map so as to achieve accurate recognition of test substances by FAIMS.