C反应蛋白(CRP)是一种具有多种生物活性的细胞因子,其合成部位在肝脏,通过炎症反应诱导胰岛素抵抗(IR)。IR是胰岛素介导的组织葡萄糖摄取和利用能力下降。正常妊娠期存在IR,是一种生理适应性改变。妊娠期糖尿病(GDM)的发病与IR有关,在妊娠期间体内CRP水平发生变化,与妊娠妇女及GDM患者的IR有十分重要的关系,CRP在妊娠母体水平的升高为妊娠生理和病理现象提供相关的理论依据,为GDM未来风险预测及临床治疗有效性的评估有一定的价值和意义。 C-reactive protein (CRP) is a cytokine that has a variety of biological activities, the synthesis of which in the liver, induces insulin resistance (IR) through the inflammatory response. IR is insulin-mediated tissue glucose uptake and utilization decreased. The presence of IR during normal pregnancy is a physiological change. The incidence of gestational diabetes mellitus (GDM) is associated with IR and changes in vivo CRP levels during pregnancy are associated with IR in pregnant women and GDM patients. Elevated maternal levels of CRP contribute to pregnancy physiology and pathology Relevant theoretical basis for the GDM future risk prediction and evaluation of the effectiveness of clinical treatment has some value and significance.