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目的探讨联合检测乙型病毒性肝炎五项、前S1抗原与乙型肝炎病毒脱氧核糖核酸(HBV-DNA)的临床关系,评估其在乙型肝炎病毒(HBV)检测中的临床价值。方法将2011年9月至2013年9月于我院接受治疗的100例乙型病毒性肝炎表面抗原阳性患者作为研究对象,收集其临床资料,采集所有患者肘静脉血液,并选用定量法与酶联免疫吸附试验进行乙型病毒性肝炎五项、前S1抗原及HBV-DNA检测,评估其临床价值。结果在不同的乙型病毒性肝炎五项模式下,前S1抗原与HBV-DNA检测结果比较差异无统计学意义(P>0.05);两组患者HBV-DNA与乙型病毒性肝炎前S1抗原检出符合率比较差异无统计学意义(P>0.05)。结论选用乙型病毒性肝炎前S1抗原与HBV-DNA联合检测能提高乙型病毒性肝炎的检出率,指导其治疗与预后有重要意义。
Objective To investigate the clinical significance of combined detection of hepatitis B virus (HBV), pre-S1 antigen and hepatitis B virus DNA (HBV-DNA) in the detection of hepatitis B virus (HBV). Methods A total of 100 cases of HBsAg positive patients treated in our hospital from September 2011 to September 2013 were selected as the research object. The clinical data were collected and all the patients’ elbow venous blood was collected. The quantitative method and enzyme The combined immunosorbent assay for hepatitis B virus five, pre-S1 antigen and HBV-DNA test to assess its clinical value. Results There was no significant difference in the detection results of pre-S1 antigen and HBV-DNA between the five patterns of hepatitis B virus infection (P> 0.05). HBV-DNA and HBV pre-S1 antigen No significant difference was found in the coincidence rate (P> 0.05). Conclusion The combination of HBV pre-S1 antigen and hepatitis B virus can improve the detection rate of hepatitis B and guide its treatment and prognosis.