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目的 探讨新生儿窒息致多系统器官功能衰竭(MSOF)的高危因素及防治的关键问题.方法分析于出生48小时内发生MOSF的107例重度窒息地临床资料.结果 本组患儿均有肺功能衰竭,都以肺功能衰竭或包括肺的功能衰竭器官群首发;患儿病死率;受累器官为2、3、4、5个以上组分别是22.2%、52.2%、77.8%、100.0%,出生胎龄为～28周,～不足37、37周以上组分别是66.7%、44.4%、24.6%,生后发生MSOF时间为～12h、～24h、～48h组分别是46.5%、34.2%、19.3%.结论 受累脏器愈多,胎龄愈小,MSOF发生愈早,其病死率愈高.尽早处理宫内窘迫及有效复苏,阻断肺动脉高压造成的恶性循环,是防止继发其他功能衰竭的关键.
Objective To investigate the risk factors of multiple system organ failure (MSOF) caused by neonatal asphyxia and the key problems of prevention and treatment.Methods The clinical data of 107 severe asphyxia patients who developed MOSF within 48 hours after birth were analyzed.Results The lung function Failure, all with lung failure or failure of the lungs, including organ failure group; children with mortality; affected organs 2,3,4,5 groups were 22.2%, 52.2%, 77.8%, 100.0% were born The gestational age ranged from ~ 28 weeks, ~ less than 37 and 37 weeks, respectively, which were 66.7%, 44.4% and 24.6% respectively. MSOF was ~ 12h after birth, 46.5%, 34.2% and 19.3 % .Conclusion The more organs involved, the smaller the gestational age, the earlier the MSOF occurs, and the higher the mortality is.The early treatment of intrauterine distress and effective resuscitation, blocking the vicious circle caused by pulmonary hypertension is to prevent secondary to other failure key.