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作者曾证实RA患者血清和滑膜液内含有能抑制健康人非特异性Ts细胞活性的因子。含大量IC、高滴度RF的血清和滑膜滲出液标本,具有很强的抗抑制活性。已知RA患者非特异性Ts细胞功能受抑的原因之一是单核巨噬细胞系统的细胞产生的炎症介质PGE_2过多,而IC则能引起单核巨噬细胞系统激活。本文作者进一步证实:(1) 含IC的RA患者滑膜液能抑制PHA、组织
The authors have demonstrated that RA patients’ serum and synovial fluid contain factors that inhibit the activity of nonspecific Ts cells in healthy individuals. Contains a large number of IC, high titer RF serum and synovial effusion specimens, has a strong anti-inhibitory activity. It is known that one of the reasons for the dysfunction of nonspecific Ts cells in RA patients is that cells in the monocyte-macrophage system produce too much PGE2, an inflammatory mediator, whereas ICs can cause systemic activation of mononuclear macrophages. The authors further confirmed: (1) synovial fluid containing RA in patients with IC can inhibit PHA, tissue