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目的探讨厄贝沙坦联合左旋氨氯地平在老年高血压尿微量白蛋白中的应用效果。方法 2011年3月—2013年9月收治高血压肾病患者203例,随机分为三组,A组、B组68例,C组67例。A组采用左旋氨氯地平2.5mg口服,每日1次;B组用厄贝沙坦150mg口服,每日1次;C组厄贝沙坦分散片150mg加左旋氨氯地平2.5mg口服,每日1次,均治疗12周。结果三组治疗前后血压和尿微量白蛋白均有显著下降;厄贝沙坦组尿微量白蛋白下降明显优于左旋氨氯地平组;厄贝沙坦联合左旋氨氯地平组在降压和降低尿微量白蛋白明显优于二药单独治疗组。结论厄贝沙坦联合左旋氨氯地平治疗高血压肾病疗效显著,安全可靠,二者有协同作用,值得推广应用。
Objective To investigate the application of irbesartan and levamlodipine in elderly patients with hypertension and microalbuminuria. Methods From March 2011 to September 2013, 203 patients with hypertensive nephropathy were randomly divided into three groups: A group, B group, 68 cases and C group, 67 cases. A group of oral levamlodipine 2.5mg, once daily; B group with irbesartan 150mg orally, once daily; C group irbesartan dispersible tablets 150mg plus levamlodipine 2.5mg orally, each Day 1, are treated for 12 weeks. Results Before and after treatment, blood pressure and urinary microalbumin decreased significantly in all three groups. Urinary albumin in irbesartan group was significantly lower than that in levamlodipine group. Irbesartan combined with levamlodipine group decreased blood pressure and decreased Urine microalbumin was significantly better than the two drugs alone treatment group. Conclusion Irbesartan combined with levamlodipine treatment of hypertensive nephropathy significant effect, safe and reliable, the two have synergistic effects, it is worth promoting the application.