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目的:黄芩苷作为黄芩的主要成分之一,其制剂虽应用广泛,但存在较多缺点,如水溶液不稳定、口服吸收差、生物利用度不高及药物体内半衰期短等从而导致用药剂量大且频繁给药。本文目的是研究丁香花蕾精油及其微乳对黄芩苷体外经皮渗透性的影响。方法:采用Valia-Chien扩散池,以生理盐水为接受液,不同浓度的丁香花蕾精油以及以丁香花蕾精油作为微乳的油相及促进剂进行大鼠离体皮肤的体外渗透实验。结果:黄芩苷微乳的平均粒径为41.3±5.1 nm,多分散指数为0.18,表明该制剂粒径小且均一。微乳(不含丁香花蕾精油)、丁香花蕾精油及含丁香花蕾精油的微乳对黄芩苷均有不同程度的增渗作用。其中,含丁香花蕾精油的微乳对黄芩苷的促渗作用最强。结论:丁香花蕾精油以及以丁香花蕾精油作为微乳的油相对黄芩苷均有一定的促进渗透作用。
OBJECTIVE: Baicalin, one of the main components of Scutellaria baicalensis, has many disadvantages, such as instability of aqueous solution, poor oral absorption, low bioavailability and short half-life of drug in vivo, Frequent administration. The purpose of this paper is to study the effects of clove flower bud essential oil and its microemulsion on the in vitro permeability of baicalin. Methods: In vitro permeation experiments of isolated rat skin were carried out using Valia-Chien diffusion cell, physiological saline as receiving solution, different concentrations of clove bud essential oil and clove bud essential oil as the microemulsion oil phase and accelerant. Results: The average particle size of baicalin microemulsion was 41.3 ± 5.1 nm and the polydispersity index was 0.18, indicating that the particle size was small and uniform. Microemulsion (not including clove flower bud essential oil), clove flower bud essential oil and clove bud essential oil microemulsion have different degree of infiltration of baicalin. Among them, the microemulsion containing clove flower essential oil has the strongest promoting effect on baicalin. Conclusion: Clove bud essential oil and clove bud essential oil as microemulsion relative to baicalin have a certain role in promoting the infiltration.