雷公藤总甙可引起大、小鼠体重减轻,犬和大鼠食欲减退及犬的白细胞和血小板降低,对三种动物的心、肝、肾无明显影响;它能损伤犬及大、小鼠睾丸生殖上皮,抑制精原细胞分裂导致各级生殖细胞减少和消失,在配对实验中可引起小鼠生育减少及不育,此作用在阈下剂量即可发生,但有可逆性,且不影响睾丸间质细胞;雷公藤总甙的安全范围较生药提高1倍。 Tripterygium glycosides can cause weight loss in large and small mice, loss of appetite in dogs and rats, and decreased canine and thrombocytopenic purpura in dogs, with no significant effect on the heart, liver and kidneys of the three animals; it can damage dogs and large and small mice Testicular reproductive epithelium, inhibition of spermatogonial division led to the reduction and disappearance of germ cells at all levels, in the paired experiments can cause reduced fertility in mice and infertility, this effect can occur in the subthreshold dose, but reversible, and does not affect Testicular interstitial cells; Tripterygium glycosides range of safety than medicine to enhance 1 times.