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目的探讨淋巴细胞平均体积、淋巴细胞平均电导和淋巴细胞平均光散射等VCS参数在传染性单核细胞增多症患儿中的变化及意义。方法 Beckman-Coulter LH750全自动血细胞分析仪检测50例传染性单核细胞增多症患儿急性发作期、恢复期及50例健康体检儿童外周血标本,统计分析WBC、L以及MLV、MLC和MLS等VCS参数结果。结果传染性单核细胞增多症急性期WBC、L、MLV、MLC、MLS明显高于恢复期和对照组,差异有统计学意义(P<0.05),传染性单核细胞增多症恢复期各参数与对照组差异无统计学意义(P>0.05)。传染性单核细胞增多症组MLV、MLC与异型淋巴细胞比值(ALY)呈正相关(r=0.315、0.495,P<0.05)。ROC曲线分析MLV、MLC、MLS的曲线下面积分别为0.574、0.911、0.756,其中MLC的cut-off值≥114.1时,敏感性和特异性达86.5%和88.7%。结论传染性单核细胞增多症急性期淋巴细胞VCS参数存在异常变化,在血常规检查的同时提供MLV、MLC、MLS等参数,或有助于传染性单核细胞增多症的临床诊断和病情判断。MLC或可作传染性单核细胞增多症患儿快速诊断的理想指标。
Objective To investigate the changes and significance of VCS parameters such as mean lymphocyte volume, average lymphocyte average conductance and average lymphocyte mean light scattering in children with infectious mononucleosis. Methods The peripheral blood samples of 50 children with infectious mononucleosis were detected by Beckman-Coulter LH750 automatic hemocyte analyzer in 50 children with acute infectious disease, convalescence and 50 healthy children. Statistical analysis of WBC, L, MLV, MLC and MLS VCS parameter results. Results The levels of WBC, L, MLV, MLC and MLS in the acute phase of infectious mononucleosis were significantly higher than those in the recovery and control groups (P <0.05). The parameters of recovery of infectious mononucleosis There was no significant difference with the control group (P> 0.05). There was a positive correlation between MLV, MLC and ALY in infectious mononucleosis group (r = 0.315,0.495, P <0.05). The area under the curve of MLV, MLC and MLS of ROC curve analysis were 0.574, 0.911 and 0.756, respectively. The sensitivity and specificity of MLC were 86.5% and 88.7% when the cut-off value of MLC was ≥114.1. Conclusions There are abnormal changes of VCS parameters in acute lymphocytic leukemia of infectious mononucleosis. MLV, MLC, MLS and other parameters may be provided in blood routine examination, which may be helpful for the clinical diagnosis and judgment of infectious mononucleosis . MLC or can be used as an ideal indicator of rapid diagnosis of infectious mononucleosis in children.