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补体C_3是一种大分子物质,正常小儿尿中无C_3排出,尿中C_3的出现可反映肾小球滤膜的损害程度。本文对86名各种小儿肾小球疾病尿C_3含量的测定结果,表明尿C_3阳性者主要见于肾炎性肾病、乙肝肾炎及慢性肾炎。大多数单纯性肾病均为阴性,急性链球菌感染后肾炎则全部阴性。提示尿C_3检测对于单纯性肾病与肾炎性肾病、乙肝肾炎与急性链球菌感染后肾炎的鉴别具有一定意义。尿C_3阳性组蛋白尿选择性指数(SPI)多为非选择性及中度选择性,对激素反应差;尿C_3阴性组SPI多为高度选择性,对激素反应好;表明尿C_3测定对于小儿肾病综合征予测激素疗效及早期合理用药具有指导意义。尿C_3动态观察可看出尿C_3转阴或下降者病情趋向好转或缓解,增高或阴性转阳者提示病情活动或恶化,有助于判断对治疗的反应。此外尿C_3阳性者尿IgM阳性检出率显著高于尿C_3阴性者,提示对估计小儿肾小球疾病的严重程度及予后判断也有一定价值。
Complement C_3 is a macromolecular substance, normal urine C_3 excretion, urine C_3 appears to reflect the extent of damage to the glomerular filtration membrane. In this paper, 86 children with glomerular disease urinary C_3 determination of the results showed that urine C_3 positive mainly seen in nephritis, hepatitis B nephritis and chronic nephritis. Most simple nephropathy were negative, but nephritis after acute streptococcal infection was all negative. Prompt urinary C_3 detection of simple nephropathy and nephritis, nephritis and hepatitis B nephritis identification of acute infection is of some significance. Urine C_3-positive histoneuria index (SPI) mostly non-selective and moderate selectivity, poor response to the hormone; urine C_3-negative group of SPI are highly selective and good hormone response; that urinary C_3 determination of pediatric Nephrotic syndrome hormone therapy efficacy and early rational use of drugs is instructive. Urine C_3 dynamic observation can be seen urinary C_3 negative or decline in the disease tends to improve or alleviate the situation, increased or negative yang who prompted the disease activity or deterioration, help to determine the response to treatment. In addition urine C_3 positive urinary IgM positive detection rate was significantly higher than urine C_3 negative, suggesting that the evaluation of children with glomerular disease severity and post-prognosis also have some value.