我们已经开发了全电动光学分辨率的光声显微镜,它集成了5个互为补充的扫描模式,可以提供2.6μm横向分辨率的高速宽场成像,同时可以测量包括血流速度、血氧含量、氧代谢率等诸多重要生理参数。在一维的M-mode机械扫描模式下,我们可以实现在活体的血管横截面上各处血流速度的测量。在二维的光学扫描模式下,在50×50μm2的视场范围内,我们可以获得50 Hz帧速来实现对活体内细胞活动的实时监测。在光学机械同步 We have developed an all-electric optical-resolution photoacoustic microscope that integrates five complementary scanning modes that provide high-speed wide-field imaging with a horizontal resolution of 2.6 μm and can measure blood flow velocity, , Oxygen metabolism rate and many other important physiological parameters. In one-dimensional M-mode mechanical scanning mode, we can measure the velocity of blood flow throughout the vascular cross-section of the living body. In the two-dimensional optical scanning mode, we can obtain a 50 Hz frame rate to realize real-time monitoring of cell activity in vivo in a field of view of 50 × 50 μm2. In optical mechanical synchronization