本文对16例IgM 肾病及39例其他类型的肾小球疾病患者,应用免疫荧光技术观察α_2巨球蛋白(α_2M)与IgM 在肾小球内沉积的关系,探讨IgM 肾病系膜区IgM 沉积的机理。81%的IgM 肾病患者系膜区同时有IgM 和α_2M 沉积,其它类型的原发性肾小球疾病二者同时阳性的多未超过50%;继发性肾小球损害者IgM 全部阳性,但α_2M 无一例阳性。由于α_2M 不参予免疫反应,因此认为IgM 肾病患者的IgM沉积可能是一种非特异的滞留。 This article 16 cases of IgM nephropathy and 39 cases of other types of glomerular disease, immunofluorescence technique observed α 2 macroglobulin (α 2 M) and IgM in the glomerular deposition of the relationship between IgM nephropathy IgM deposition mechanism. 81% of IgM nephropathy mesangial area both IgM and α 2 M deposition, other types of primary glomerular disease both positive and more than 50%; IgM secondary glomerular lesions were all positive, but α_2M no positive cases. Since α_2M does not participate in the immune response, it is believed that IgM deposition in patients with IgM nephropathy may be a non-specific retention.