帕金森病是以多巴胺能神经元缺损为特征的变性疾病,氧化应激反应已被认为是导致黑质细胞死亡的主要发病机制。谷胱甘肽作为脑内最重要的抗氧化保护机制之一,可能起始氧化应激介导的神经元死亡,参与帕金森病的发病机制。本文就谷胱甘肽的生物学特征、功能及与帕金森病的关系作一综述。 Parkinson’s disease is a degenerative disorder characterized by dopaminergic neuronal defects. Oxidative stress has been identified as the primary pathogenesis leading to the death of the substantia nigra. Glutathione, one of the most important antioxidative protection mechanisms in the brain, may initiate oxidative stress-mediated neuronal death and participate in the pathogenesis of Parkinson’s disease. In this paper, the biological characteristics of glutathione, its function and the relationship with Parkinson’s disease are reviewed.