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目的:观察丹莪妇康煎膏联合布洛芬缓释胶囊治疗原发性痛经的临床疗效。方法:将227例原发性痛经患者随机分为三组:治疗组、对照1组、对照2组。治疗组给予丹莪妇康煎膏联合布洛芬缓释胶囊治疗,对照1组为布洛芬缓释胶囊单药治疗,对照2组为丹莪妇康煎膏单药治疗。各组给药3个月经周期,测定停药3个月后PGF2α、PGE2与血液流变学的变化与临床效果。结果:丹莪妇康煎膏联合布洛芬缓释胶囊中西结合治疗原发性痛经的总有效率为93.50%,单独给药布洛芬缓释胶囊与单独给药丹莪妇康煎膏治疗原发性痛经的有效率分别为86.67%与89.33%。治疗组与对照2组治疗前后原发性痛经患者不同切变率下的全血粘度、红细胞压积及红细胞最大聚集指数显著降低(P<0.05),红细胞变形能力显著增强(P<0.05)。对照1组无明显改变。三组在治疗前后血液中PGF2α与PGE的含量存在显著性差异(P<0.05),各组间PGF2α与PGE的改变无统计学意义。结论:丹莪妇康煎膏联合布洛芬缓释胶囊通过改善血液的流变性,降低血液粘度及红细胞的聚集状态,提高红细胞的变形能力,有效改善子宫微循环,并可降低血液中PGF2α的表达,增加PGE的表达从而共同起到治疗原发性痛经的作用。
Objective: To observe the clinical curative effect of Dan E Fukang Jianpi combined with ibuprofen sustained release capsules in the treatment of primary dysmenorrhea. Methods: 227 patients with primary dysmenorrhea were randomly divided into three groups: treatment group, control group 1, control group 2. The treatment group was given Dan E Fukang Jianpi combined with ibuprofen sustained release capsules treatment, the control group 1 was treated with ibuprofen sustained release capsules, the control group 2 Dan Dan Fukang ointment monotherapy. Each group was given 3 menstrual cycles, and the changes and clinical effects of PGF2α, PGE2 and hemorheology after 3 months’ withdrawal were measured. Results: The total effective rate of Dan E Fukang Decoction combined with ibuprofen sustained release capsules in the treatment of primary dysmenorrhea was 93.50%. The ibuprofen sustained release capsules alone and the Dancao Fukang ointment alone The effective rates of primary dysmenorrhea were 86.67% and 89.33% respectively. The whole blood viscosity, hematocrit and erythrocyte maximum aggregation index (P <0.05) and the erythrocyte deformability were significantly increased (P <0.05) in patients with primary dysmenorrhea before and after treatment. Control 1 group no significant change. The levels of PGF2α and PGE in the blood before and after treatment in the three groups were significantly different (P <0.05). The changes of PGF2α and PGE in the three groups were not statistically significant. Conclusion: Dan Curcumin cream combined with ibuprofen sustained release capsules can improve the deformability of erythrocytes, improve uterine microcirculation and decrease PGF2α in the blood by improving the rheological properties of the blood, reducing the blood viscosity and the aggregation state of the red blood cells Expression, increase the expression of PGE together play a role in the treatment of primary dysmenorrhea.